(hier klicken für deutsche version)
web-page was created in gratitude and responsibility, to forward experiences and
developed know-how to a few MAS-treating M.D.´s and a few MAS-concerned.
In 1980 only 160 MAS-cases occurred in the medical
The MASyndrome appears rarely world-wide (sporadic)
and I was counted as N° 6 by Prof. Dr. Brabant, Endocrinologe of the
This means: 6 concerned compared to 82 million people
would like to say “thank you” to Mr. Dr. Groß, who retired around
2000 from the Annastift hospital in
Groß believed in me, in our success, a healthy future and more important
he even told me.
I would like to say “thank you” to Mrs. Prof. Dr. Hüter from
The McCune-Albright-Syndrome appears in various
evolutionary stages and shows-up differently.
Main characteristic for this “female concerned” on
this web-page is the mainly strong appearance of defaults in the right-hand side
of the female-body:
hip, breast, thyroid gland (cysts),
a personally known concerned male shows strong
appearance of defaults in the left-hand side of his male-body.
Early Symptoms: menstruation praecox when
being a baby/infant (!), followed by premature development of secondary
characteristics = pubertas praecox, boys show this only in exception
Main symptoms: 1. strongly contrasted café-au-lait
spots, occur on neck, face, back, shoulders and hip. Symptom varies to not
appear at all.
2. spontaneous fractures and /or deformation of the skeletal system (mainly
on “proximale femur” – thigh – characterized by fibrous dysplasia.
3. endocrine dysfunction appears to arise from autonomous hyperfunction
of involved glands: thyroid, adrenal, pituitary, ovaries.
Hyperthyroid, cushing syndrome, acromegaly,
source of the illness is:
The syndrome results from a postzygotic somatic
(dominant) mutation in some cells, which shows-up only in a mosaic-binding with
healthy cells (all the daughter cells of the embryonic cell in which the initial
mutation occurred also contain the mutation:
a chain of e.g. 8 green(=healthy) cells and 1 red (=mutated) cell, another 8
green and another 1 red cell.
cell-division: green cells produce other healthy green cells, and the red-one
will produce another red cell.
earlier the mutation occurs in embryogenesis, the more widespread the tissue of
involvement. Mutations late in embryogenesis are mild cases.
always takes 2 auto-somatic chromosomes, so every auto-somatic gene is twice
are the same chromosomes of the origin of mother and father (=homologe).
Auto-somatic means that no sex-chromosome is concerned.
is the gene with the mutation, compared to the genes of regular chromosomes.
domination is comparable to the well-know “dark hair + dark eyes” hereditary.
No risk for siblings, no chance to hand-over to
the next generation.
somatic mosaic is spread within the cells à
one cell mutates and also spreads.
23 chromosomes of the female ovum + 23 chromosomes of the male sperm à
cell-division: 2-4-8-16…..if 1 cell of this cell-binding mutates à
another cell-division of this binding will produce more mutated cells, which
will spread among regular healthy cells within the embryo-body.)
a fertilized egg (female) would already carry a mutated chromosome, then all
cells would carry this mutation. A fertilization would not lead to a pregnancy.
This condition/state does not agree upon life (lethal=mortal).
within a mosaic-binding the illness is able to develop.
Clinic symptoms: a female concerned, born in
vaginal bleeding at the age of 1 year, as a baby,
3d year on: once annual
café-au-lait sport: a light pigment spot of a size of
a 2-dollar-coin, shown on the top of the right-hand
pubertas praecox with 9 years, right-hand side:
lymph-knot removal (right-hand loin), university-clinic
1972: tissue sample of right-hand thigh-bone (suspect
of bone-cancer) Annastift hospital,
1973: right femur (thigh-bone) fracture due to
butter-soft bones, adding a long piece of 5 inches “strong bone”, cut-off
the shin-bone, after surgery: walking only with a splint (no regular walking at
1974: bone-softness takes over on left-hand side
thigh-bone (a cyst-filling was made), fresh bone was added from the hip to fill
in and strengthen the soft thigh-bone - no walking at all: wheel chair,
1975: still no walking
1976: adjusting the balance of the hip by cutting a
wedge of 30° off the thigh-bone, tighten with a clamp and 4 screws. Walking
only with 2 crutches, Annastift
1977: removal of clamp and screws (which took 4 hours
since the new bone grew all over it)
Hormone-treatment: a female concerned:
No treatment done when being an infant
(mainly since no other case was available)
Treatment after thyroid-gland surgery in 2000:
TSH-hormone “L-thyroxin”, 50 nano grams
Endocrine consultation (hormone specialist),
follow yellow-pages and check within the next bigger city at university-clinics.
OA Dr. med. Christoph
Facharzt für Innere Medizin
Endokrinologe und Diabetologe
Abteilung Gastroenterologie, Hepatologie und Endokrinologie
Medizinische Hochschule Hannover
phone.: +49 – (0)511 - 532 - 3196
Consultations in terms of bones/fibrous dysplasia:
Find a specialist at hospitals which is famous
Germany e.g.: Annastift
Prof. Dr. C.Wirth
phone.: +49 (0)511 – 5354 - 340
and contact: firstname.lastname@example.org
The MAGIC foundation in the
Female concerned: alteration in the body:
1989: dripping mamma/breast (right-hand side)
1994: muscle-growth removal off the uterus (as big as a
removal of a ”knot” off of the right breast
1997: removal of an small-egg sized haematome off the
2004: after a long break, showing-up again at the
endocrine-center of the MHH, meeting Mr. Prof. Dr. Brabant
Undergoing some blood- and hormone/urine-tests
A bone-structure measurement was done by DEXA, result:
showing a regular bone-structure around the thigh-bone and loin-vertebra area.
An activated bone-metabolism was found.
taking “vitamin D3” (since 2004)
a healthy team-work between body, soul and nutrition maybe holds down the
dimension of the body-alteration and keeps it on a lower level.
any coffee (!)and white-sugar
Coffee and white-sugar “steals” precious calcium of the bone-structure
daily fresh fruit: “an apple a day keeps the doctor away”
less cheese (due to fat & calories and low sports activities)
daily plain joghurt (50-100 grams), with glucose only or fresh fruit
1 -1,5 liter of still water, butter-milk (mainly)
or green-tea with honey to sweeten
IN MIND: always find a reason to laugh about !!
Special thanks to: good co-operation with the
MH-Hanover, Div. Human Genetic: